I believe (and I'm happy to be corrected if I'm wrong) that a "cent" is not a fixed amount, but is rather simply (by definition) 1/100 of the distance between two semitones (i.e., adjacent notes). This would be so even though the "distance" in Hz between two adjacent semitones will be different from one octave to the next. So, no, if you're flattening the E by 12.5 cents, you'll want to flatten it by 12.5 cents regardless of octave.
Ah Ha.. a voice of experience education and reasoning.
Cajun Tuning is tuning bey a Cajun.. As a Cajun Accordeon is one made by a Cajun.
"Cajun" tuning is variable ..as in Savoy who cuts corners and saves time and money by abbreviating what has been traditionally know as "Cajun " tuning. This is one method or style or formula of just" tuning pre dating Cajuns by a couple thousand years.